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CAPN2 / Calpain 2 / M-Calpain
calpain 2, (m/II) large subunit
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | calpain 2, (m/II) large subunit |
| Family/Subfamily: | Protease , Cysteine C2 |
| Synonyms: | CAPN2, Calpain 2, large subunit, Calpain ii, Calpain, large polypeptide L2, Calpain-2 catalytic subunit, Calpain 2, Calpain large polypeptide L2, Calpain-2 large subunit, CANP 2, Calpain M-type, CANP2, CANPL2, CANPml, M-type calpain, M-calpain, MCANP, Millimolar-calpain |
| Target Sequences: | NM_001748 NP_001739.2 P17655 |
Publications (2)
1
The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M. Scientific reports. 2017 7:11771. (WB; Human)
[Full Text Article]
[PubMed:28924170]
[PMC:PMC5603515]
Related Antibodies: LS-B12657.
2
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Wang Y, Hersheson J, Lopez D, Hammer M, Liu Y, Lee KH, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, Coutelier M, Brice A, Stevanin G, Durr A, Bi X, Houlden H, Baudry M. Cell reports. 2016 16:79-91. (WB; Human)
[Full Text Article]
[PubMed:27320912]
Related Antibodies: LS-B12657.
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Antibodies
(40)
Type
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(40)
Target
CAPN2 / Calpain 2 / M-Calpain
(40)
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Human
(36)
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(10)
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(9)
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(2)
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(3)
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(4)
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(14)
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(9)
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(33)
Flo
(4)
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(12)
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(1)
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(3)
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rabbit
(33)
mouse
(7)
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(3)
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(20)
IgG1
(1)
IgG2a
(5)
IgG2b
(1)
Clonality
monoclonal mc
(7)
polyclonal pc
(33)
Clone
1381CT669.7.66.71
(1)
1F4
(2)
2E2F2
(1)
OTI3G1
(2)
Format
AP Conjugated
(1)
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(1)
APC Conjugated
(2)
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(4)
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(2)
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(1)
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(1)
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(4)
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(4)
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(2)
Unconjugated
(21)
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aa45-514
(8)
aa1-324
(4)
Internal
(1)
Lys354
(1)
aa10-43
(1)
aa305-354
(1)
Publications
No
(39)
Yes
(1)
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (1F4) Antibody
Mouse, Rat, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (Lys354) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (1381CT669.7.66.71) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (OTI3G1) Antibody
Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (Carrier-free) (OTI3G1) Antibody
Dog, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (Carrier-free) (1F4) Antibody
Mouse, Rat, Human, Monkey
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
10 µg/$318; 100 µg/$470
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal Antibody
Mouse, Human, Monkey
Flo, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CAPN2 / Calpain 2 / M-Calpain Mouse anti-Human Monoclonal (2E2F2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$459
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$394
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (aa305-354) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (AP) Antibody
Mouse, Rat, Human
IHC, WB
AP Conjugated
20 µl/$287; 100 µl/$431
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (aa10-43) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$448
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Human Polyclonal (aa45-514) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
CAPN2 / Calpain 2 / M-Calpain Rabbit anti-Pig Polyclonal (aa1-324) Antibody
Pig
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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of 40
product results
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