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Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.
Gene Name: | calpain 10 |
Family/Subfamily: | Protease , Cysteine C2 |
Synonyms: | CAPN10, Calpain-10, Calpain-like protease CAPN10, CANP10, KIAA1845, NIDDM1, Calpain 10, CANP 10 |
Target Sequences: | NM_023083 NP_075571.1 Q9HC96 |
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