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The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Gene Name: | calpain 1, (mu/I) large subunit |
Family/Subfamily: | Protease , Cysteine C2 |
Synonyms: | CAPN1, Calpain i, Calpain mu-type, Calpain, large polypeptide L1, Calpain-1 catalytic subunit, Calpain 1, Calpain-1 large subunit, CANP, CANP1, Mu CANP, Mu-calpain, Mu-type calpain, MuCANP, Micromolar-calpain, MuCL, CANP 1, CANPL1 |
Target Sequences: | BC008751 AAH08751.1 P07384 |
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