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CAMK2B / CaMKII Beta
calcium/calmodulin-dependent protein kinase II beta
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
| Gene Name: | calcium/calmodulin-dependent protein kinase II beta |
| Family/Subfamily: | Protein Kinase , CAMK2 |
| Synonyms: | CAMK2B, Beta-subunit of CaMK II, Cam kinase II beta, CaMK IIbeta, CaM-kinase II beta chain, CAMKB, Beta CaMK II, CaM kinase II beta subunit, CaM kinase II subunit beta, CaM kinase IIbeta, CAM2, Camk ii beta, CAMK2, CaMKII beta, CaMK-II subunit beta, CaMKIIbeta |
| Target Sequences: | NM_001220 NP_001211.3 Q13554 |
Publications (2)
1
CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca2+ Signals during LTP Induction, but Not Maintenance. Chang JY, Parra-Bueno P, Laviv T, Szatmari EM, Lee SR, Yasuda R. Neuron. 2017 May;94:800-808. (Rat)
[Full Text Article]
[PubMed:28521133]
[PMC:PMC5573161]
Related Antibodies: LS-B5767.
2
Generation and behavior characterization of CaMKII beta knockout mice. Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ. PloS one. 9:e105191. [Full Text Article]
[PubMed:25127391]
[PMC:PMC4134274]
Related Antibodies: LS-B5767.
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CAMK2B / CaMKII Beta Mouse anti-Rat Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
CAMK2B / CaMKII Beta Mouse anti-Rat Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$1,104
CAMK2B / CaMKII Beta Mouse anti-Rat Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,104
CAMK2B / CaMKII Beta Mouse anti-Rat Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,104
CAMK2B / CaMKII Beta Mouse anti-Rat Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,104
CAMK2B / CaMKII Beta Mouse anti-Rat Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,104
CAMK2B / CaMKII Beta Mouse anti-Human Monoclonal (S11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal (aa499-513) Antibody
Rat, Human
ELISA, ICC, IF, WB
Unconjugated
100 µl/$386
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Pig, Horse, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
CAMK2B / CaMKII Beta Mouse anti-Human Monoclonal (aa311-385) (OTI8D9) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
CAMK2B / CaMKII Beta Mouse anti-Human Monoclonal (aa311-385) (Carrier-free) (OTI8D9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal (350-430 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
CAMK2B / CaMKII Beta Mouse anti-Human Monoclonal (C-Terminus) (1050CT14.1.3) Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
200 µl/$393
CAMK2B / CaMKII Beta Rabbit anti-Mouse Polyclonal (aa168-196) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CAMK2B / CaMKII Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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