CAMK1 / CAMKI

calcium/calmodulin-dependent protein kinase I

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca2+ elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

CAMK1 / CAMKI (9)

Publications

No (9)

Tag

6His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His,C-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human CAMK1 / CAMKI Protein (Recombinant 6His, C-terminus) (Met1-Leu370) - LS-G39248

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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CAMK1 / CAMKI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100094

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.2 kDa

Price:

100 µg/$494

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Human CAMK1 / CAMKI Protein (Recombinant) (Leu2-Leu370) - LS-G97220

Source:

E. coli

Tag:

None

Molecular Weight:

41.5 kDa

Price:

50 µg/$502

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Human CAMK1 / CAMKI Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70834

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.2 kDa

Price:

20 µg/$1,107

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Human CAMK1 / CAMKI Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88127

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.2 kDa

Price:

20 µg/$150

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Human CAMK1 / CAMKI Protein (Recombinant GST, N-terminus) (aa271-370) - LS-G60767

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CAMK1 / CAMKI Protein (Recombinant) (Met1-Leu370) - LS-G132714

Source:

E. coli

Tag:

None

Molecular Weight:

45.0kDa

Price:

10 µg/$262; 50 µg/$339; 200 µg/$642; 100 µg/$512; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Human CAMK1 / CAMKI Protein (Recombinant His,C-terminus) (Met1-Leu370) - LS-G139828

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human CAMK1 / CAMKI Protein (Recombinant GST) (Full Length) - LS-G31194

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66.33 kDa

Price:

10 µg/$479; 25 µg/$670

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