CALR / Calreticulin

calreticulin

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

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Products

ELISA Kits (31)

Type

Cell-Based (1)

Competitive EIA (2)

Custom (5)

Development Kit (3)

Sandwich (17)

Sandwich CLIA (3)

Target

CALR / Calreticulin (31)

Reactivity

Human (9)

Mouse (8)

Rat (8)

Chicken (1)

Dog (1)

Guinea pig (1)

Monkey (1)

Pig (2)

Rabbit (1)

Product Group

DevKit DuoPlus (3)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (5)

96-Well Strip Plate (21)

Antibody Pair and Standard (3)

Publications

No (31)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (4)

Cell Lysates (3)

Plasma (21)

Serum (21)

Tissue Homogenates (7)

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Mouse/Human/Rat CALR / Calreticulin (Cell-Based ELISA) ELISA Kit - LS-F3080

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F6663

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$715

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Human CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F20965

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F4728

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$798

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Human CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F26799

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Mouse CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F17452

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat CALR / Calreticulin (CLIA) ELISA Kit - LS-F31136

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Rat

Range:

15.63 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F21321

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Rat CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F8021

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$750

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Bovine CALR / Calreticulin (Custom ELISA) ELISA Kit - LS-F17449

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human CALR / Calreticulin (Custom ELISA) ELISA Kit - LS-F17451

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Pig CALR / Calreticulin (Custom ELISA) ELISA Kit - LS-F17450

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Dog CALR / Calreticulin (Custom ELISA) ELISA Kit - LS-F17454

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat CALR / Calreticulin (Custom ELISA) ELISA Kit - LS-F17455

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F37480

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse CALR / Calreticulin (CLIA) ELISA Kit - LS-F30543

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Human CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F34505

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F49868

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.3 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$610

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DevKit DuoPlus Mouse CALR / Calreticulin ELISA Development Kit - LS-F71925

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,254; 1000 Wells/$1,867

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DevKit DuoPlus Rat CALR / Calreticulin ELISA Development Kit - LS-F72147

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

500 Wells/$1,305; 1000 Wells/$1,952

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Human CALR / Calreticulin (Competitive EIA) ELISA Kit - LS-F55425

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

2.47 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$764

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DevKit DuoPlus Human CALR / Calreticulin ELISA Development Kit - LS-F71798

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

6.24 - 400 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,229; 1000 Wells/$1,826

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Chicken CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F41884

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Guinea pig CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F41885

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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Monkey CALR / Calreticulin (Sandwich ELISA) ELISA Kit - LS-F41886

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

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