CALCRL / CGRP Receptor

calcitonin receptor-like

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension.

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Products

Proteins (2)

Type

Recombinant (2)

Target

CALCRL / CGRP Receptor (2)

Publications

No (2)

Tag

GST (1)

GST, N-terminus (1)

Species

Human (2)

Source

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CALCRL / CGRP Receptor Protein (Recombinant GST, N-terminus) (aa23-132) - LS-G61416

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CALCRL / CGRP Receptor Protein (Recombinant GST) (Full Length) - LS-G32010

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.34 kDa

Price:

10 µg/$479; 25 µg/$670

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