CACNA2D2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

CACNA2D2 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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CACNA2D2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130395

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

130.3 kDa

Price:

100 µg/$710

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Human CACNA2D2 Protein (Recombinant GST, N-terminus) (aa65-162) - LS-G61050

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CACNA2D2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79938

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

130.3 kDa

Price:

20 µg/$215

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Human CACNA2D2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67477

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

130.3 kDa

Price:

20 µg/$1,107

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