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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
Gene Name: | calcium channel, voltage-dependent, L type, alpha 1F subunit |
Family/Subfamily: | Ion Channel , Calcium channel - alpha subunit Cav1 |
Synonyms: | CACNA1F, AIED, Alpha 1f, Cav1.4, CORDX, CSNXB2, Ca(v)1.4, CACNAF1, Cav1.4alpha1, CSNBX2, COD3, COD4, CORDX3, CSNB2, CSNB2A, JMC8, JM8, OA2 |
Target Sequences: | NM_005183 NP_005174.2 O60840 |
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