Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
CACNA1C / Cav1.2
calcium channel, voltage-dependent, L type, alpha 1C subunit
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
| Gene Name: | calcium channel, voltage-dependent, L type, alpha 1C subunit |
| Family/Subfamily: | Ion Channel , Calcium channel - alpha subunit Cav1 |
| Synonyms: | CACNA1C, Alpha 1c, CaV1.2, CACH2, CACNL1A1, CCHL1A1, DHPR, alpha-1 subunit, DHP receptor, DHPr, LQT8, TS, CACN2 |
| Target Sequences: | NM_000719 NP_000710.5 Q13936 |
Publications (4)
1
Specific antibodies to the external vestibule of voltage-gated potassium channels block current. Zhou BY, Ma W, Huang XY. The Journal of general physiology. 1998 111:555-63.
[PubMed:9524138]
[PMC:PMC2217123]
2
Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration. Yang S, Huang XY. The Journal of biological chemistry. 2005 280:27130-7.
[PubMed:15911622]
3
A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. Yang CH, Huang CC, Hsu KS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:7550-62. (WB; Rat)
[PubMed:22649233]
☰ Filters
Products
Antibodies
(37)
Type
Primary
(37)
Target
CACNA1C / Cav1.2
(37)
Reactivity
Human
(27)
Mouse
(24)
Rat
(14)
Hamster
(1)
Rabbit
(9)
Application
IHC
(20)
IHC-Fr
(1)
IHC-P
(4)
WB
(30)
ELISA
(6)
ICC
(8)
IF
(9)
IP
(10)
Peptide-ELISA
(2)
Host
rabbit
(24)
mouse
(10)
goat
(1)
rabbit-new zealand white
(2)
Product Group
IHCPlus
(2)
Isotype
IgG
(9)
IgG1
(1)
IgG1,k
(1)
IgG2b
(8)
Clonality
monoclonal mc
(10)
polyclonal pc
(27)
Clone
4D10
(1)
S57-46
(8)
Format
APC
(1)
APC Conjugated
(2)
Atto 390 Conjugated
(1)
Atto 488 Conjugated
(1)
Atto 594 Conjugated
(1)
Biotin Conjugated
(3)
Cy3 Conjugated
(1)
Cy7 Conjugated
(1)
FITC Conjugated
(3)
HRP Conjugated
(2)
PE Conjugated
(1)
PerCP Conjugated
(1)
RPE Conjugated
(1)
Unconjugated
(19)
Epitope
aa1507-1733
(8)
aa1978-2139
(8)
C-Terminus
(4)
Internal
(2)
aa2237-2249
(1)
aa50-100
(1)
pSer1928
(1)
Publications
No
(36)
Yes
(1)
Fast Shipping
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (pSer1928) Antibody
Rabbit, Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
200 µl/$468
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
100 µg/$665
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$393
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Rat, Human
WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
CACNA1C / Cav1.2 Rabbit anti-Mouse Polyclonal (aa1978-2139) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Biotin) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Biotin Conjugated
100 µg/$475
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (FITC) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
FITC Conjugated
100 µg/$472
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Atto 594) (S57-46) Antibody
Mouse, Rat, Hamster, Human
ICC, IF, IHC, IP, WB
Atto 594 Conjugated
100 µg/$479
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (APC) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
APC Conjugated
100 µg/$478
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Atto 390) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 390 Conjugated
100 µg/$479
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (Atto 488) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 488 Conjugated
100 µg/$479
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (PerCP) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PerCP Conjugated
100 µg/$478
CACNA1C / Cav1.2 Mouse anti-Rabbit Monoclonal (aa1507-1733) (RPE) (S57-46) Antibody
Rabbit, Mouse, Rat, Human
ICC, IF, IHC, IP, WB
RPE Conjugated
100 µg/$477
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
CACNA1C / Cav1.2 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
CACNA1C / Cav1.2 Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µg/$466
CACNA1C / Cav1.2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CACNA1C / Cav1.2 Mouse anti-Human Monoclonal (4D10) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Viewing 1-25
of 37
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
