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To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.
Gene Name: | calcium binding tyrosine-(Y)-phosphorylation regulated |
Synonyms: | CABYR, CABYRc/d, Calcium-binding protein 86, Cancer/testis antigen 88, CABYRe, CBP86, Fibrousheathin 2, Fibrousheathin II, FSP-2, FSP2, CABYRa, CABYRc, CT88, Fibrousheathin-2 |
Target Sequences: | NM_012189 NP_036321.2 O75952 |
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