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Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration.
Gene Name: | calcium binding protein 1 |
Synonyms: | CABP1, CALBRAIN, Calcium binding protein 5, Calcium-binding protein 1, Caldendrin, CABP, Calcium binding protein 1, HCALB_BR |
Target Sequences: | NM_004276 NP_004267.2 Q9NZU7 |
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