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CA2 / Carbonic Anhydrase II

carbonic anhydrase II

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

Gene Name: carbonic anhydrase II
Synonyms: CA2, CA-II, CAII, CAC, Car2, Carbonate dehydratase II, Carbonic anhydrase C, Carbonic anhydrase II, Carbonic dehydratase, Carbonic anhydrase 2, Carbonic anhydrase B
Target Sequences: NM_000067 NP_000058.1 P00918

Publications (6)

1
Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L. The Journal of biological chemistry. 2002 277:36085-91. [PubMed:12138085]
2
Inhibition of cell growth and nuclear factor-kappaB activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503. Shiah HS, Gao W, Baker DC, Cheng YC. Molecular cancer therapeutics. 2006 5:2484-93. [PubMed:17041092]
3
Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cells. Li Y, Tu C, Wang H, Silverman DN, Frost SC. The Journal of biological chemistry. 2011 286:15789-96. [PubMed:21454639] [PMC:PMC3091188]
4
Role of zinc in catalytic activity of carbonic anhydrase IX. Tu C, Foster L, Alvarado A, McKenna R, Silverman DN, Frost SC. Archives of biochemistry and biophysics. 2012 521:90-4. (WB; Human) [PubMed:22465027] [PMC:PMC3345035]
5
Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease. Melissa Lee, Briana Vecchio-Pagán, Neeraj Sharma, Abdul Waheed, Xiaopeng Li, Karen S Raraigh, Sarah Robbins, Sangwoo T Han, Arianna L Franca, Matthew J Pellicore, Taylor A Evans, Kristin M Arcara, Hien Nguyen, Shan Luan, Deborah Belchis, Jozef Hertecant, Joseph Zabner, William S Sly, Garry R Cutting. Human molecular genetics. 2016 May;25:1923-1933. [Full Text Article] [PubMed:26911677] [PMC:PMC5062583]
6
Quantitative Secretome Analysis Reveals Clinical Values of Carbonic Anhydrase II in Hepatocellular Carcinoma. Xiaohua Xing, Hui Yuan, Hongzhi Liu, Xionghong Tan, Bixing Zhao, Yingchao Wang, Jiahe Ouyang, Minjie Lin, Xiaolong Liu, Aimin Huang. Genomics, proteomics & bioinformatics. 2021 Feb;;19:94-107. [Full Text Article] [PubMed:33662630] [PMC:PMC8498920]
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ELISA Kits (33)
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Custom (4)
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Sandwich (21)
Sandwich CLIA (3)
CA2 / Carbonic Anhydrase II (33)
Human (9)
Mouse (5)
Rat (7)
Chicken (4)
Guinea pig (1)
Monkey (2)
Porcine (1)
Rabbit (1)
Rhesus monkey (2)
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12 x 8-Well Microstrips (3)
96-Well Microplate (5)
96-Well Strip Plate (20)
Antibody Pair and Standard (4)
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Cell Culture Supernatants (8)
Cell Lysates (6)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (24)
Saliva (1)
Serum (25)
Tissue Homogenates (11)
Urine (1)
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$685
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Microplate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
Human
156 - 10000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Saliva, Serum, Urine
1 Plate/$901
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
CA2 / Carbonic Anhydrase II ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,238; 1000 Wells/$1,841
CA2 / Carbonic Anhydrase II ELISA Kit
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Development Kit
Antibody Pair and Standard
Chicken
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
CA2 / Carbonic Anhydrase II ELISA Kit
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Development Kit
Antibody Pair and Standard
Rhesus monkey
6.24 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
500 Wells/$1,302; 1000 Wells/$1,947
CA2 / Carbonic Anhydrase II ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,089; 1000 Wells/$1,589
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Rhesus monkey
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$748
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CA2 / Carbonic Anhydrase II ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
CA2 / Carbonic Anhydrase II ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
CA2 / Carbonic Anhydrase II ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Microplate
Rat
2.813 - 180 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CA2 / Carbonic Anhydrase II ELISA Kit
Select
Sandwich
96-Well Microplate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Human
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CA2 / Carbonic Anhydrase II ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CA2 / Carbonic Anhydrase II ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CA2 / Carbonic Anhydrase II ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CA2 / Carbonic Anhydrase II ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CA2 / Carbonic Anhydrase II ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).