C9orf72 / ALSFTD

Chromosome 9 open reading frame 72

C9orf72 plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a hexanucleotide repeat in non-coding sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.

☰ Filters

Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

C9orf72 / ALSFTD (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

Human C9orf72 / ALSFTD Protein (Recombinant GST) (Full Length) - LS-G36982

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.7 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human C9orf72 / ALSFTD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G95677

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.6 kDa

Price:

20 µg/$150

Select

C9orf72 / ALSFTD Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106856

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24.6 kDa

Price:

100 µg/$494

Viewing 1-3 of 3 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.