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C8orf4 is a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
Gene Name: | Chromosome 8 Open Reading Frame 4 |
Synonyms: | C8orf4, Thyroid cancer protein 1, HTC-1, Human thyroid cancer 1, TC-1, TC1 |
Target Sequences: | NM_020130 NP_064515.1 Q9NR00 |
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