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C14orf169 / NO66

chromosome 14 open reading frame 169

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation By similarity. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

Gene Name: chromosome 14 open reading frame 169
Synonyms: C14orf169, NO66, HsNO66, Nucleolar protein 66, MAPJD
Target Sequences: NM_024644 NP_078920.2 Q9H6W3

☰ Filters
Products
Antibodies (12)
Primary (12)
C14orf169 / NO66 (12)
Human (12)
Mouse (3)
Rat (3)
Bovine (1)
Chimpanzee (3)
Dog (1)
Hamster (1)
Horse (1)
Monkey (4)
Pig (4)
IHC (2)
WB (10)
DB (1)
ELISA (3)
IP (2)
Peptide-ELISA (1)
rabbit (9)
mouse (2)
goat (1)
IgG (9)
IgG1 (2)
monoclonal mc (2)
polyclonal pc (10)
3354C5a (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (9)
aa67-116 (4)
aa1-50 (1)
aa463-473 (1)
aa50-100 (1)
No (12)
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
C14orf169 / NO66 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer tissue  using C14orf169 Polyclonal Antibody at dilution of 1:45(×200)
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
C14orf169 / NO66 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue  using C14orf169 Polyclonal Antibody at dilution of 1:45(×200)
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
C14orf169 / NO66 Antibody - Western blot analysis of immunized recombinant protein, using anti-C14orf169 monoclonal antibody.
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C14orf169 / NO66 Mouse anti-Human Monoclonal (3354C5a) Antibody
Human
DB, WB
Unconjugated
100 µg/$486
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
C14orf169 / NO66 Antibody - Antibody (0.3 ug/ml) staining of A431 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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C14orf169 / NO66 Goat anti-Human Polyclonal (aa463-473) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Select
C14orf169 / NO66 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
50 µg/$558
C14orf169 / NO66 Antibody - HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal (aa67-116) Antibody
Human
WB
Unconjugated
100 µl/$397
C14orf169 / NO66 Antibody - HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal (aa67-116) (HRP) Antibody
Pig, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100 µl/$442
C14orf169 / NO66 Antibody - HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal (aa67-116) (Biotin) Antibody
Pig, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$442
C14orf169 / NO66 Antibody - HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
C14orf169 / NO66 Rabbit anti-Human Polyclonal (aa67-116) (FITC) Antibody
Pig, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$442
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).