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C11orf2 / Fat-Free
vacuolar protein sorting 51 homolog (S. cerevisiae)
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.
| Gene Name: | vacuolar protein sorting 51 homolog (S. cerevisiae) |
| Synonyms: | VPS51, ANG2, Another new gene 2 protein, C11orf2, C11orf3, FFR, Fat-free homolog, Protein fat-free homolog, ANG3 |
| Target Sequences: | NM_013265 NP_037397.2 Q9UID3 |
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