c-Met

met proto-oncogene

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

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Products

ELISA Kits (21)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (6)

Sandwich (10)

Sandwich Phosphorylation (1)

Target

c-Met (21)

Reactivity

Human (14)

Mouse (7)

Rat (6)

Canine (1)

Dog (2)

Pig (1)

Format

96-Well Microplate (10)

96-Well Strip Plate (11)

Publications

No (21)

Sample Type

Adherent Cell Cultures (4)

Cell Culture Supernatants (4)

Plasma (10)

Serum (10)

Tissue Homogenates (3)

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Mouse/Human/Rat Phospho-c-Met (Tyr1234) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1564

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-c-Met ELISA Kit - LS-F340

Type:

Sandwich Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$661

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Mouse c-Met (Sandwich ELISA) ELISA Kit - LS-F385

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.082 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$610

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Human c-Met (Sandwich ELISA) ELISA Kit - LS-F24459

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

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Human c-Met (Sandwich ELISA) ELISA Kit - LS-F349

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

61.44 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Dog/Canine c-Met (Custom ELISA) ELISA Kit - LS-F322

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Dog, Canine

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$823

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Mouse/Human/Rat c-Met (Cell-Based ELISA) ELISA Kit - LS-F2143

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human c-Met (Sandwich ELISA) ELISA Kit - LS-F2660

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

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Mouse/Human/Rat Phospho-c-Met (Tyr1356) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1188

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Human c-Met (Sandwich ELISA) ELISA Kit - LS-F7595

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.25 - 80 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

Select

Human c-Met (Sandwich ELISA) ELISA Kit - LS-F12029

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

Select

Human c-Met (Sandwich ELISA) ELISA Kit - LS-F36281

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human c-Met (Sandwich ELISA) ELISA Kit - LS-F54699

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$744

Select

Human c-Met (Sandwich ELISA) ELISA Kit - LS-F20741

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Human c-Met (Sandwich ELISA) ELISA Kit - LS-F26988

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

250 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Bovine c-Met (Custom ELISA) ELISA Kit - LS-F20468

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Dog c-Met (Custom ELISA) ELISA Kit - LS-F20470

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Pig c-Met (Custom ELISA) ELISA Kit - LS-F20472

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Rat c-Met (Custom ELISA) ELISA Kit - LS-F20473

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse c-Met (Custom ELISA) ELISA Kit - LS-F20469

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse/Human/Rat Phospho-c-Met (Tyr1349) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1565

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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