c-Met

met proto-oncogene

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

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Products

Antibodies (196)

Type

Primary (196)

Target

c-Met (196)

Reactivity

Human (178)

Mouse (88)

Rat (43)

Bat (1)

Bovine (2)

Chicken (1)

Cynomolgus (1)

Dog (10)

Guinea pig (1)

Horse (1)

Monkey (3)

Pig (2)

Rabbit (5)

Sheep (2)

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Application

IHC (54)

IHC-Fr (1)

IHC-P (10)

WB (157)

Flo (11)

DB (7)

ELISA (107)

ICC (4)

IF (30)

IP (6)

Peptide-ELISA (12)

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Host

rabbit (130)

mouse (65)

sheep (1)

Product Group

IHCPlus (4)

Isotype

IgG (83)

IgG1 (53)

IgG2a (4)

IgG2b (4)

Clonality

monoclonal mc (71)

polyclonal pc (125)

Clone

001 (1)

261 (1)

4AT247 (1)

4AT259 (1)

4AT44 (2)

5E9B7 (1)

5E9C4 (1)

6AT1785 (1)

6AT1877 (1)

6AT203 (1)

OTI18A5 (2)

OTI1A8 (2)

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UMAB190 (2)

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Format

Agarose Conjugated (1)

APC (1)

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Cy3 Conjugated (1)

Cy7 Conjugated (1)

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HRP Conjugated (13)

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Preservative Free (3)

Unconjugated (127)

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Epitope

pTyr1349 (15)

pTyr1234/Tyr1235 (10)

pTyr1356 (9)

aa1092-1379 (8)

aa570-885 (8)

pTyr1234 (7)

C-Terminus (6)

aa125-421 (6)

pTyr1003 (6)

1290-1370 aa (2)

p1349 (2)

pTyr1230/Tyr1234/Tyr1235 (2)

pTyr1235 (2)

pTyr1349/1356 (2)

1170-1250 aa (1)

1300-1380 aa (1)

950-1030 aa (1)

Cytoplasmic Domain (1)

Glu999 (1)

Internal (1)

Thr1343 (1)

Tyr1234 (1)

aa1201-1250 (1)

aa1316-1365 (1)

aa208-407 (1)

aa276-325 (1)

aa586-601 (1)

aa976-1025 (1)

p1003 (1)

p1234 (1)

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Publications

No (193)

Yes (3)

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IHC-plus™ c-Met Antibody (Cytoplasmic Domain) LS-B2812

(5.0) Rating

(3) Publication(s)

Antibody:

c-Met Mouse anti-Human Monoclonal (Cytoplasmic Domain) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated

Price:

50 µl/$615

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c-Met Antibody (clone 6AT203) LS-C96426

(4.0) Rating

(1) Publication(s)

Antibody:

c-Met Mouse anti-Human Monoclonal (6AT203) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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IHC-plus™ c-Met Antibody (C-Terminus) LS-B3345

(4.0) Rating

Antibody:

c-Met Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

250 µl/$505

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IHC-plus™ c-Met Antibody (clone 4AT44) LS-B6889

(4.0) Rating

Antibody:

c-Met Mouse anti-Human Monoclonal (4AT44) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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c-Met Antibody (PE) LS-C486962

Antibody:

c-Met Rabbit anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$233; 100 Tests/$263

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c-Met Antibody (clone 6AT1785) LS-C96427

Antibody:

c-Met Mouse anti-Human Monoclonal (6AT1785) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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c-Met Antibody (clone 5E9C4) LS-C682401

Antibody:

c-Met Mouse anti-Human Monoclonal (5E9C4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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c-Met Antibody (clone 5E9B7) LS-C682403

Antibody:

c-Met Mouse anti-Human Monoclonal (5E9B7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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c-Met Antibody (phospho-Tyr1349/1356) LS-C60102

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1349/1356) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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c-Met Antibody LS-C499316

Antibody:

c-Met Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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c-Met Antibody (phospho-Tyr1356) LS-C96910

(4.0) Rating

(1) Publication(s)

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1356) Antibody

Reactivity:

Human

Applications:

DB

Format:

Unconjugated

Price:

400 µl/$393

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c-Met Antibody (Tyr1234, Azide-free) LS-C72459

Antibody:

c-Met Mouse anti-Human Monoclonal (Tyr1234) (Azide-free) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IP, WB

Format:

Unconjugated, Azide-free

Price:

100 µl/$813

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c-Met Antibody (aa276-325) LS-C199258

Antibody:

c-Met Rabbit anti-Human Polyclonal (aa276-325) Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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c-Met Antibody (phospho-Tyr1003) LS-C800988

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1003) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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c-Met Antibody (PE) LS-C486541

Antibody:

c-Met Rabbit anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$233; 100 Tests/$263

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c-Met Antibody (phospho-Tyr1234/Tyr1235, Agarose) LS-C130724

Antibody:

c-Met Rabbit anti-Human Monoclonal (pTyr1234/Tyr1235) (Agarose) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Agarose Conjugated

Price:

400 µl/$702

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IHC-plus™ c-Met Antibody (aa1316-1365) LS-B8031

(4.0) Rating

Antibody:

c-Met Rabbit anti-Human Polyclonal (aa1316-1365) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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c-Met Antibody (phospho-Tyr1349) LS-C96909

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1349) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

c-Met Antibody (clone 4AT44) LS-C45687

Antibody:

c-Met Mouse anti-Human Monoclonal (4AT44) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$938

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c-Met Antibody (phospho-Tyr1003) LS-C37359

Antibody:

c-Met Rabbit anti-Human Monoclonal (pTyr1003) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$702

Select

c-Met Antibody (phospho-Tyr1234) LS-C117416

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1234) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

c-Met Antibody (clone 001, Preservative Free) LS-C819283

Antibody:

c-Met Rabbit anti-Mouse Monoclonal (Preservative Free) (001) Antibody

Reactivity:

Mouse

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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c-Met Antibody (aa208-407) LS-C344046

Antibody:

c-Met Rabbit anti-Human Polyclonal (aa208-407) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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c-Met Antibody (clone 261, Preservative Free) LS-C818915

Antibody:

c-Met Rabbit anti-Human Monoclonal (Preservative Free) (261) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$271; 100 µl/$412

Select

c-Met Antibody (phospho-Tyr1003) LS-C822264

Antibody:

c-Met Rabbit anti-Human Polyclonal (pTyr1003) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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