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C/EBP Epsilon / CEBPE is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
Gene Name: | CCAAT/enhancer binding protein (C/EBP), epsilon |
Synonyms: | CEBPE, CRP1, C/EBP epsilon, C/EBP-epsilon |
Target Sequences: | NM_001805 NP_001796.2 Q15744 |
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