BTK

Bruton agammaglobulinemia tyrosine kinase

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

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Antibodies (94)

Proteins (12)

ELISA Kits (10)

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Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (1)

Over-Expression Lysate (2)

Primary (94)

Recombinant (10)

Sandwich (7)

Target

BTK (116)

Reactivity

Human (88)

Mouse (35)

Rat (32)

Bovine (4)

Chicken (1)

Dog (2)

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Non-Human Primate (1)

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rabbit (67)

mouse (27)

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monoclonal mc (27)

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Yes (1)

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10His, N-terminus (1)

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E. coli (3)

HEK 293 Cells (2)

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Wheat Germ Extract (2)

Yeast (1)

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Low Endotoxin Level

Low endotoxin level (2)

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BTK Antibody (phospho-Tyr223) LS-C180161

(4.0) Rating

(1) Publication(s)

Antibody:

BTK Rabbit anti-Human Polyclonal (pTyr223) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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BTK Antibody (phospho-Tyr223, Biotin) LS-C180846

Antibody:

BTK Rabbit anti-Human Polyclonal (pTyr223) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

0.1 ml/$416

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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IHC-plus™ BTK Antibody LS-B4855

(4.0) Rating

Antibody:

BTK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$440

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Human BTK (Sandwich ELISA) ELISA Kit - LS-F5728

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human BTK (Sandwich ELISA) ELISA Kit - LS-F10964

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human BTK Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G22827

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

78.1 kD

Price:

1 mg/$1,607; 100 µg/$469; 20 µg/$349

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BTK Antibody LS-C455

Antibody:

BTK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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Mouse/Human/Rat Phospho-BTK (Tyr223) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1072

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse BTK (Sandwich ELISA) ELISA Kit - LS-F10965

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

Select

BTK Antibody (aa27-55, Biotin) LS-C252771

Antibody:

BTK Rabbit anti-Human Polyclonal (aa27-55) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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BTK Antibody (Biotin) LS-C498458

Antibody:

BTK Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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BTK Antibody LS-C331556

Antibody:

BTK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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BTK Antibody (phospho-Tyr551) LS-C353914

Antibody:

BTK Rabbit anti-Human Polyclonal (pTyr551) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Human, Monkey

Applications:

ICC, IF, IP, WB

Format:

Unconjugated

Price:

100 µl/$315

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BTK Antibody (aa209-239, Biotin) LS-C275703

Antibody:

BTK Rabbit anti-Human Polyclonal (aa209-239) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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BTK Antibody (clone OTI3D11) LS-C115133

Antibody:

BTK Mouse anti-Human Monoclonal (OTI3D11) Antibody

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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BTK Antibody (clone OTI3A2) LS-C115135

Antibody:

BTK Mouse anti-Human Monoclonal (OTI3A2) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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BTK Antibody (clone OTI3A2, Carrier-free) LS-C784617

Antibody:

BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI3A2) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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BTK Antibody (aa396-659, Biotin) LS-C686492

Antibody:

BTK Rabbit anti-Human Polyclonal (aa396-659) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279

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Human BTK Protein (Recombinant His-GST) (aa396-659) - LS-G14467

Source:

E. coli

Tag:

His-GST

Molecular Weight:

57.9 kDa

Price:

10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272

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BTK Antibody (clone OTI12D4) LS-C115131

Antibody:

BTK Mouse anti-Human Monoclonal (OTI12D4) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

BTK Antibody (clone OTI6H9) LS-C115134

Antibody:

BTK Mouse anti-Human Monoclonal (OTI6H9) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

BTK Antibody (clone OTI6H9, Carrier-free) LS-C784613

Antibody:

BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI6H9) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

BTK Antibody (clone OTI1H7) LS-C115141

Antibody:

BTK Mouse anti-Human Monoclonal (OTI1H7) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

BTK Antibody (clone OTI15G8) LS-C115158

Antibody:

BTK Mouse anti-Human Monoclonal (OTI15G8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

BTK Antibody (clone OTI15G8, Carrier-free) LS-C784629

Antibody:

BTK Mouse anti-Human Monoclonal (Carrier-free) (OTI15G8) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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