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RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Gene Name: | CUGBP, Elav-like family member 5 |
Synonyms: | CELF5, Brunol5, CELF-5, Bruno-like protein 5, CUG-BP and ETR-3 like factor 5, BRUNOL-5, RNA-binding protein BRUNOL-5 |
Target Sequences: | NM_021938 NP_068757.2 Q8N6W0 |
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