Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Gene Name: | CUGBP, Elav-like family member 4 |
Synonyms: | CELF4, BRUNOL-4, Brunol5, CELF-4, Bruno-like protein 4, CUG-BP and ETR-3 like factor 4, LYST-interacting protein LIP9, RNA-binding protein BRUNOL-4, BRUNOL4, RNA-binding protein BRUNOL4 |
Target Sequences: | NM_020180 NP_064565.1 Q9BZC1 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.