BRSK2

BR serine/threonine kinase 2

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.

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Products

Antibodies (26)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (26)

Recombinant (2)

Target

BRSK2 (30)

Reactivity

Human (19)

Mouse (13)

Rat (5)

Application

IHC (11)

IHC-P (1)

WB (25)

ELISA (16)

IF (1)

IP (1)

Peptide-ELISA (1)

Host

rabbit (24)

mouse (1)

rabbit-new zealand white (1)

Isotype

IgG (18)

Clonality

monoclonal mc (1)

polyclonal pc (25)

Clone

D29B6 (1)

Format

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (13)

Epitope

aa329-356 (7)

aa706-736 (7)

Internal (4)

N-Terminus (1)

Publications

No (30)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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BRSK2 Antibody (N-Terminus, clone D29B6) LS-C183762

Antibody:

BRSK2 Rabbit anti-Human Monoclonal (N-Terminus) (D29B6) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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BRSK2 Antibody LS-C19697

Antibody:

BRSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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BRSK2 Antibody (aa706-736) LS-C326950

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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BRSK2 Antibody (aa706-736, Biotin) LS-C218702

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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BRSK2 Antibody (aa706-736, FITC) LS-C218703

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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BRSK2 Antibody (aa706-736, APC) LS-C218701

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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BRSK2 Antibody (aa706-736, Azide-free, HRP) LS-C218704

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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BRSK2 Antibody (aa706-736, PE) LS-C218705

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

BRSK2 Antibody LS-C659818

Antibody:

BRSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

BRSK2 Antibody (aa706-736) LS-C99084

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (aa706-736) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

BRSK2 Antibody (aa329-356) LS-C319884

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

BRSK2 Antibody (aa329-356, Biotin) LS-C212957

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

BRSK2 Antibody (aa329-356, FITC) LS-C212958

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

BRSK2 Antibody (aa329-356, APC) LS-C212956

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

BRSK2 Antibody (aa329-356, PE) LS-C212961

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

BRSK2 Antibody (aa329-356, Azide-free, HRP) LS-C212960

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

BRSK2 Antibody LS-C832756

Antibody:

BRSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

BRSK2 Antibody LS-C829302

Antibody:

BRSK2 Rabbit-New Zealand White anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

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BRSK2 Antibody LS-C779566

Antibody:

BRSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$357

Select

BRSK2 Antibody LS-C810278

Antibody:

BRSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

BRSK2 Antibody (aa329-356) LS-C164307

Antibody:

BRSK2 Rabbit anti-Mouse Polyclonal (aa329-356) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

BRSK2 Antibody (Internal) LS-C345635

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

BRSK2 Antibody (Internal, HRP) LS-C480153

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (Internal) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

BRSK2 Antibody (Internal, Biotin) LS-C480151

Antibody:

BRSK2 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin

• Unconjugated
• HRP
• Biotin

Select

BRSK2 Antibody LS-C306576

Antibody:

BRSK2 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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