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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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BRIP1 / BACH1
BRCA1 interacting protein C-terminal helicase 1
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Gene Name:
BRCA1 interacting protein C-terminal helicase 1
Synonyms:
BRIP1, BRCA1-interacting protein 1, Fanconi anemia group J protein, FANCJ, Protein FACJ
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM. Cell. 2001 105:149-60. (WB, IP; Human)
[PubMed:11301010]
2
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Circulation research. 2005 97:372-9. (IHC, WB; Mouse)
[PubMed:16051889]
3
Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy. Eelen G, Vanden Bempt I, Verlinden L, Drijkoningen M, Smeets A, Neven P, Christiaens MR, Marchal K, Bouillon R, Verstuyf A. Oncogene. 2008 27:4233-41. (IHC-P; Human)
[PubMed:18345034]
4
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, Kitao H, Maehara Y. Genes to cells : devoted to molecular & cellular mechanisms. 2012 17:962-70. (WB; Human)
[PubMed:23157317]
5
Genotyping of fanconi anemia patients by whole exome sequencing: advantages and challenges. Knies K, Schuster B, Ameziane N, Rooimans M, Bettecken T, de Winter J, Schindler D. PloS one. 2012 7:e52648. (WB; Human)
[PubMed:23285130]
[PMC:PMC3527584]
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).