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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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BrdU
Bromodeoxyuridine (BrdU)
Bromodeoxyuridine (5-bromo-2'-deoxyuridine, BrdU, BUdR, BrdUrd) is a synthetic nucleoside that is an analog of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues. 5-Bromodeoxycytidine is deaminated to form BrdU. BrdU can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle during which DNA is replicated), substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical (see immunohistochemistry), thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. BrdU can be passed to daughter cells upon replication. BrdU has been demonstrated to be detectable over two years post-infusion.
Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons. Cooper O, Isacson O. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 24:8924-31.
[PubMed:15483111]
[PMC:PMC2613225]
2
Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: dual role of replication and transcription activator. Wang Y, Tang Q, Maul GG, Yuan Y. Journal of virology. 2006 80:12171-86. (ICC)
[PubMed:17020951]
[PMC:PMC1676287]
3
CDH1 is a specific marker for undifferentiated spermatogonia in mouse testes. Tokuda M, Kadokawa Y, Kurahashi H, Marunouchi T. Biology of reproduction. 2007 76:130-41. (ICC)
[PubMed:17035642]
4
Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Swee LK, Bosco N, Malissen B, Ceredig R, Rolink A. Blood. 2009 113:6277-87.
[PubMed:19211508]
Related Antibodies: LS-C40882.
5
IL-11 regulates autoimmune demyelination. Gurfein BT, Zhang Y, Lpez CB, Argaw AT, Zameer A, Moran TM, John GR. Journal of immunology (Baltimore, Md. : 1950). 2009 183:4229-40.
[PubMed:19734214]
[PMC:PMC3027139]
6
Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Zhang Y, Argaw AT, Gurfein BT, Zameer A, Snyder BJ, Ge C, Lu QR, Rowitch DH, Raine CS, Brosnan CF, John GR. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:19162-7.
[PubMed:19855010]
[PMC:PMC2776461]
7
Environmental complexity, seasonality and brain cell proliferation in a weakly electric fish, Brachyhypopomus gauderio. Dunlap KD, Silva AC, Chung M. The Journal of experimental biology. 2011 214:794-805. (IHC)
[PubMed:21307066]
[PMC:PMC3036548]
8
Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Benatti P, Dolfini D, Vigan A, Ravo M, Weisz A, Imbriano C. Nucleic acids research. 2011 39:5356-68.
[PubMed:21415014]
[PMC:PMC3141247]
Related Antibodies: LS-C40882.
9
Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. Zhang J, Zhang Y, Dutta DJ, Argaw AT, Bonnamain V, Seto J, Braun DA, Zameer A, Hayot F, Lpez CB, Raine CS, John GR. Journal of immunology (Baltimore, Md. : 1950). 2011 187:1129-41.
[PubMed:21709156]
[PMC:PMC3164308]
10
Detection of BrdU-label retaining cells in the lacrimal gland: implications for tissue repair. You S, Tariq A, Kublin CL, Zoukhri D. Cell and tissue research. 2011 346:317-26.
[PubMed:22101331]
[PMC:PMC3245820]
11
Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. Tveden-Nyborg P, Vogt L, Schjoldager JG, Jeannet N, Hasselholt S, Paidi MD, Christen S, Lykkesfeldt J. PloS one. 2012 7:e48488. (ICC, IHC; Guinea pig)
[PubMed:23119033]
[PMC:PMC3485340]
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).
