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Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Gene Name: | BRCA1 associated protein |
Synonyms: | BRAP, BRAP2, IMP, Galectin-2-binding protein, RING finger protein 52, RNF52, BRCA1 associated protein, BRCA1-associated protein |
Target Sequences: | NM_006768 NP_006759.3 Q7Z569 |
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