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BPIFA1 / SPLUNC1

BPI fold containing family A, member 1

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.

Gene Name: BPI fold containing family A, member 1
Synonyms: BPIFA1, BA49G10.5, Lung-specific protein X, LUNX, Ligand-binding protein RYA3, SPLUNC1, SPURT, Von Ebner protein Hl, LPLUNC3, NASG, PLUNC, Protein Plunc
Target Sequences: NM_016583 NP_057667.1 Q9NP55

Publications (1)

1
Increased expression of BPI fold-containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma. Wang H, Jiang D, Li W, Wang S. Oncology letters. 2017 October;14:4231-4236. (Human) [Full Text Article] [PubMed:28943932] [PMC:PMC5604161] Related Antibodies: LS-B3549.

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Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
BPIFA1 / SPLUNC1 (10)
No (10)
6His-SUMO, N-terminus (1)
GST (1)
His (1)
His-GST (1)
Myc-DDK (Flag) (6)
Human (8)
293T Cells (2)
E. coli (3)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (3)
BPIFA1 / SPLUNC1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
BPIFA1 / SPLUNC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
24.6 kDa
20 µg/$150
BPIFA1 / SPLUNC1 Protein - Recombinant  Palate/Lung And Nasal Epithelium Associated Protein By SDS-PAGE
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E. coli
His-GST
54.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
BPIFA1 / SPLUNC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.71 kDa
100 µg/$494
BPIFA1 / SPLUNC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
24.6 kDa
100 µg/$494
BPIFA1 / SPLUNC1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
100 µg/$1,128; 20 µg/$721
BPIFA1 / SPLUNC1 Protein - Purified recombinant protein BPIFA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
24.6 kDa
20 µg/$1,107
BPIFA1 / SPLUNC1 Protein - Purified recombinant protein BPIFA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
24.6 kDa
20 µg/$1,107
BPIFA1 / SPLUNC1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
26.71 kDa
20 µg/$150
BPIFA1 / SPLUNC1 Protein - 12.5% SDS-PAGE of human PLUNC stained with Coomassie Blue
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Wheat Germ Extract
GST
53.9 kDa
10 µg/$479; 25 µg/$670
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).