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The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Gene Name: | bactericidal/permeability-increasing protein |
Synonyms: | BPI, BPIFD1, CAP 57, RBPI |
Target Sequences: | NM_001725 NP_001716.2 P17213 |
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