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BP1 / DLX4

distal-less homeobox 4

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.

Gene Name: distal-less homeobox 4
Synonyms: DLX4, Beta protein 1, BP1, DLX7, DLX8, DLX9, Distal-less homeo box 7, Distal-less homeo box 9, Distal-less homeobox 4, Homeobox protein DLX-7, Homeobox protein DLX-8, Homeobox protein DLX-4
Target Sequences: NM_001934 NP_001925.2 Q92988

Publications (2)

1
BP1 transcriptionally activates bcl-2 and inhibits TNFalpha-induced cell death in MCF7 breast cancer cells. Stevenson HS, Fu SW, Pinzone JJ, Rheey J, Simmens SJ, Berg PE. Breast cancer research : BCR. 2007 9:R60. (WB; Human) [PubMed:17854498] [PMC:PMC2242656]
2
Identification and molecular characterization of a new member of the peritrophic membrane proteins from the meadow moth, loxostege sticticalis. Yin J, Wei ZJ, Li KB, Cao YZ, Guo W. International journal of biological sciences. 2010 6:491-8. [PubMed:20827401] [PMC:PMC2935671]

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
BP1 / DLX4 (7)
No (7)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (4)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
BP1 / DLX4 Protein - 12.5% SDS-PAGE of human DLX4 stained with Coomassie Blue
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Wheat Germ Extract
GST
52.7 kDa
2 µg/$439
BP1 / DLX4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$150
BP1 / DLX4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
18.7 kDa
20 µg/$150
BP1 / DLX4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BP1 / DLX4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
18.7 kDa
100 µg/$494
BP1 / DLX4 Protein
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E. coli
His, N-Terminal
26.3 kDa
50 µg/$419
BP1 / DLX4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).