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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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Additional Contact Details
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BOB / GPR15
G protein-coupled receptor 15
G protein-coupled receptor GPR15 is an Orphan-A GPCR with an unknown ligand. Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use BOB/GPR15 for productive infection, suggesting that this cofactor may play a role in HIV-1 pathogenesis and transmission.
| Gene Name: | G protein-coupled receptor 15 |
| Family/Subfamily: | GPCR , Orphan-A |
| Synonyms: | GPR15, Brother of Bonzo, G protein-coupled receptor 15, G-protein coupled receptor 15, BOB, Gpr-15 |
| Target Sequences: | NM_005290 NP_005281.1 P49685 |
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