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BMP6

bone morphogenetic protein 6

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

Gene Name: bone morphogenetic protein 6
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: BMP6, BMP-6, Bone morphogenetic protein 6, VG-1-related protein, VGR1, VG-1-R, VGR, Vg1, Vg1-related sequence, VGR-1
Target Sequences: NM_001718 NP_001709.1 P22004

Publications (2)

1
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E. EMBO molecular medicine. 2016 8:6-24. (IHC; Mouse) [Full Text Article] [PubMed:26612856] [PMC:PMC4718159]
2
Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome. Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Paola Perez, Youngmi Ji, Benjamin N French, Thomas Jf Pranzatelli, Drew G Michael, Hongen Yin, Susan S Chow, Maryam Khalaj, Sandra A Afione, Changyu Zheng, Fabiola Reis Oliveira, Ana Carolina F Motta, Alfredo Ribeiro-Silva, Eduardo M Rocha, Cuong Q Nguyen, Masayuki Noguchi, Tatsuya Atsumi, Blake M Warner, John A Chiorini. The Journal of clinical investigation. 2022 February;132:e152780. [Full Text Article] [PubMed:35113815] [PMC:PMC8920330]

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
BMP6 (10)
No (10)
GST, N-terminus (1)
His (3)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (8)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (2)
Biologically active (2)
BMP6 Protein - Recombinant Bone Morphogenetic Protein 6 By SDS-PAGE
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E. coli
His, N-Terminal
15.9 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
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HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
26.2 kDa
2 µg/$268; 10 µg/$349
BMP6 Protein
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E. coli
His
20 µg/$361; 100 µg/$544; 10 µg/$292; 50 µg/$411; 250 µg/$954; 500 µg/$1,447
BMP6 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BMP6 Protein - Purified recombinant protein BMP6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
57 kDa
20 µg/$1,107
BMP6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
57 kDa
100 µg/$710
BMP6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
57 kDa
20 µg/$215
BMP6 Protein - Human BMP-6 induces ALP in chondrogenic ATDC5 cells.
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HEK 293 Cells
None
Biologically active
Less than 0.1 ng/µg of protein.
The 117 amino acid recombinant protein has a predicted molecular mass of approximately 13 kD. Recombinant human BMP-6 is a 26.2 kD homodimeric glycoprotein. The predicted N-terminal amino acid is Val.
10 µg/$352
BMP6 Protein
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E. coli
His
19 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
BMP6 Protein
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E. coli
His
16.9 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).