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BMP1 encodes a Metallopeptidase M12A type protease that is comprised of an amino terminal signal peptide, prodomain and an astacin-like protease domain followed by CUB and EGF-like motifs. BMP1 protein has been shown to cleave chordin, the C-terminal propeptides of procollagen I, II, III and VII, pro-lysyl oxidase, probiglycan, and laminin-5, and its expression has been shown to induce cartilage and bone formation in vivo. At least six spliced variants have been reported. These share the N-terminal protease domain but differ in the C-terminus, and thus contain varying numbers of CUB and EGF-like domains.
Gene Name: | bone morphogenetic protein 1 |
Family/Subfamily: | Protease , Metallopeptidase M12A |
Synonyms: | BMP1, Bone morphogenetic protein 1, OI13, PCP-2, Procollagen C-proteinase-2, Procollagen C-proteinase, MTld, PCOLC, PCP-1, Procollagen C-endopeptidase, TLD, BMP-1, Mammalian tolloid, Mammalian tolloid protein, PCP |
Target Sequences: | NM_006129 NP_006120.1 P13497 |
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