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BMI1 / PCGF4

BMI1 polycomb ring finger oncogene

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Gene Name: BMI1 polycomb ring finger oncogene
Synonyms: BMI1, BMI-1, Flvi-2/bmi-1, FLVI2/BMI1, PCGF4, Polycomb group protein Bmi1, Polycomb complex protein BMI-1, Dna-binding protein bmi-1, Polycomb group ring finger 4, RING finger protein 51, RNF51
Target Sequences: NM_005180 NP_005171.4 P35226

Publications (1)

1
Expression and survival significance of B-cell-specific Moloney murine leukemia virus integration site 1 and matrix metalloproteinase-9 in non-small-cell lung cancer. Mu M, Song Y, Zhang B. Oncology letters. 2016 12:3715-3722. (WB; Human) [Full Text Article] [PubMed:27900059] [PMC:PMC5104154] Related Antibodies: LS-C98479.

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
BMI1 / PCGF4 (6)
No (6)
GST (2)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
BMI1 / PCGF4 Protein - 12.5% SDS-PAGE of human PCGF4 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.6 kDa
10 µg/$479; 25 µg/$670
BMI1 / PCGF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
36.8 kDa
20 µg/$150
BMI1 / PCGF4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
36.8 kDa
100 µg/$494
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E. coli
His, N-Terminal
36.9 kDa
50 µg/$419
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E. coli
GST
56.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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E. coli
His
17.3 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).