BIRC1 / NAIP

NLR family, apoptosis inhibitory protein

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

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Proteins (4)

Type

Recombinant (4)

Target

BIRC1 / NAIP (4)

Publications

No (4)

Tag

GST, N-terminus (1)

His-SUMO (1)

His-T7 (2)

Species

Human (3)

Mouse (1)

Source

E. coli (3)

Wheat Germ Extract (1)

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Human BIRC1 / NAIP Protein (Recombinant His-T7) (aa923-1148) - LS-G24348

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human BIRC1 / NAIP Protein (Recombinant His-SUMO) (aa60-345) - LS-G21662

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

48.6 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human BIRC1 / NAIP Protein (Recombinant GST, N-terminus) (aa1294-1403) - LS-G59340

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Mouse BIRC1 / NAIP Protein (Recombinant His-T7) (aa500-759) - LS-G13940

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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