BIRC1 / NAIP

NLR family, apoptosis inhibitory protein

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

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Products

Antibodies (24)

Type

Primary (24)

Target

BIRC1 / NAIP (24)

Reactivity

Human (16)

Mouse (12)

Rat (2)

Application

IHC (2)

IHC-P (2)

WB (21)

ELISA (4)

ICC (1)

IF (2)

Peptide-ELISA (2)

Host

rabbit (23)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (5)

Clonality

polyclonal pc (24)

Format

APC (2)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (10)

Epitope

aa500-759 (8)

aa923-1148 (8)

aa5-18 (1)

Publications

No (23)

Yes (1)

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IHC-plus™ BIRC1 / NAIP Antibody LS-B455

(5.0) Rating

(1) Publication(s)

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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BIRC1 / NAIP Antibody (aa500-759) LS-C295587

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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BIRC1 / NAIP Antibody (aa500-759, HRP) LS-C709841

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$335; 200 µl/$389; 500 µl/$566; 1 ml/$685; 2 ml/$922; 5 ml/$1,557

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BIRC1 / NAIP Antibody (aa500-759, Biotin) LS-C686003

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317

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BIRC1 / NAIP Antibody (aa500-759, FITC) LS-C692593

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676

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BIRC1 / NAIP Antibody (aa500-759, Cy3) LS-C700819

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

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BIRC1 / NAIP Antibody (aa500-759, APC) LS-C716933

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

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BIRC1 / NAIP Antibody (aa500-759, PE) LS-C723901

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395

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BIRC1 / NAIP Antibody (aa500-759, APC, Cy7) LS-C732894

Antibody:

BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• PE
• More...
  • APC, Cy7

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • PE
  • APC, Cy7

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BIRC1 / NAIP Antibody LS-C803675

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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BIRC1 / NAIP Antibody LS-C403351

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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BIRC1 / NAIP Antibody LS-C813907

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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BIRC1 / NAIP Antibody LS-C781007

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC-P

Format:

Unconjugated

Price:

100 µg/$357

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BIRC1 / NAIP Antibody LS-C761102

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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BIRC1 / NAIP Antibody LS-C833900

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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BIRC1 / NAIP Antibody (aa923-1148) LS-C372751

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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BIRC1 / NAIP Antibody (aa923-1148, HRP) LS-C709844

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511

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BIRC1 / NAIP Antibody (aa923-1148, Biotin) LS-C685997

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279

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BIRC1 / NAIP Antibody (aa923-1148, FITC) LS-C692592

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628

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BIRC1 / NAIP Antibody (aa923-1148, Cy3) LS-C700817

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

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BIRC1 / NAIP Antibody (aa923-1148, APC) LS-C716932

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

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BIRC1 / NAIP Antibody (aa923-1148, PE) LS-C723903

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

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BIRC1 / NAIP Antibody (aa923-1148, APC, Cy7) LS-C732893

Antibody:

BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$489; 200 µl/$614; 500 µl/$1,108; 1 ml/$1,329; 2 ml/$1,860; 5 ml/$3,487

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• PE
• More...
  • APC, Cy7

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • PE
  • APC, Cy7

Select

BIRC1 / NAIP Antibody (aa5-18) LS-C112946

Antibody:

BIRC1 / NAIP Goat anti-Human Polyclonal (aa5-18) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$401

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