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BIRC1 / NAIP

NLR family, apoptosis inhibitory protein

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.

Gene Name: NLR family, apoptosis inhibitory protein
Family/Subfamily: Apoptosis
Synonyms: NAIP, PsiNAIP, BIRC1, NLRB1
Target Sequences: NM_004536 NP_004527.2 Q13075

☰ Filters
Antibodies (24)
ELISA Kits (11)
Proteins (4)
Custom (2)
Primary (24)
Recombinant (4)
Sandwich (8)
Sandwich CLIA (1)
BIRC1 / NAIP (39)
Human (21)
Mouse (13)
Rat (2)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
IHC (2)
IHC-P (2)
WB (21)
ELISA (4)
ICC (1)
IF (2)
Peptide-ELISA (2)
rabbit (23)
goat (1)
Product Group
IHCPlus (1)
IgG (5)
polyclonal pc (24)
12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (9)
APC (2)
APC Conjugated (2)
Biotin Conjugated (2)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Unconjugated (10)
aa500-759 (8)
aa923-1148 (8)
aa5-18 (1)
No (38)
Yes (1)
Plasma (3)
Serum (3)
Tissue Homogenates (2)
GST, N-terminus (1)
His-SUMO (1)
His-T7 (2)
Human (3)
Mouse (1)
E. coli (3)
Wheat Germ Extract (1)
BIRC1 / NAIP Antibody - Anti-NAIP antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
BIRC1 / NAIP Protein - Recombinant  Neuronal Apoptosis Inhibitory Protein By SDS-PAGE
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E. coli
His-T7
29.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$335; 200 µl/$389; 500 µl/$566; 1 ml/$685; 2 ml/$922; 5 ml/$1,557
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
BIRC1 / NAIP Antibody - Western blot of recombinant BIRC1 / NAIP.
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BIRC1 / NAIP Rabbit anti-Mouse Polyclonal (aa500-759) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
BIRC1 / NAIP Antibody - Immunohistochemistry of paraffin-embedded Human brain using NAIP Polyclonal Antibody at dilution of 1:30.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
BIRC1 / NAIP Antibody - Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:100.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC-P
Unconjugated
100 µg/$357
BIRC1 / NAIP Antibody - Western blot analysis of NAIP expression in HEK293T (A), SGC7901 (B), Raw264.7 (C) whole cell lysates.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
BIRC1 / NAIP Antibody - Western blot analysis of extracts of various cell lines using NAIP Polyclonal Antibody at dilution of 1:1000.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal Antibody
Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
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BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
Select
BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
Select
BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
BIRC1 / NAIP Antibody - Western blot of BIRC1 / NAIP antibody.
Select
BIRC1 / NAIP Rabbit anti-Human Polyclonal (aa923-1148) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$489; 200 µl/$614; 500 µl/$1,108; 1 ml/$1,329; 2 ml/$1,860; 5 ml/$3,487
Select
BIRC1 / NAIP Goat anti-Human Polyclonal (aa5-18) Antibody
Human
Peptide-ELISA
Unconjugated
100 µg/$401
Viewing 1-25 of 39 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).