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BHLHB2 / DEC1
basic helix-loop-helix family, member e40
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
| Gene Name: | basic helix-loop-helix family, member e40 |
| Synonyms: | BHLHE40, BHLHB2, HLHB2, SHARP2, Stra14, SHARP-2 |
| Target Sequences: | NM_003670 NP_003661.1 O14503 |
Publications (3)
1
Identification of potential stroke targets by lentiviral vector mediated overexpression of HIF-1 alpha and HIF-2 alpha in a primary neuronal model of hypoxia. Ralph GS, Parham S, Lee SR, Beard GL, Craigon MH, Ward N, White JR, Barber RD, Rayner W, Kingsman SM, Mundy CR, Mazarakis ND, Krige D. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2004 24:245-58.
[PubMed:14747751]
2
Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Liu Y, Sato F, Kawamoto T, Fujimoto K, Morohashi S, Akasaka H, Kondo J, Wu Y, Noshiro M, Kato Y, Kijima H. Genes to cells : devoted to molecular & cellular mechanisms. 2010 15:315-25. (WB; Human)
[PubMed:20236182]
3
Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Lin Q, Cong X, Yun Z. Molecular cancer research : MCR. 2011 9:757-65. (WB; Human)
[PubMed:21571835]
[PMC:PMC3117969]
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BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Human
IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Human
IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Human
IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa249-298) Antibody
Human
WB
Unconjugated
100 µl/$424
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa350-C-term) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
BHLHB2 / DEC1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (aa1-313) (OTI10H1) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (aa1-313) (Carrier-free) (OTI10H1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (aa130-230) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$705
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated
100 µl/$904
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
100 µl/$904
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
100 µl/$904
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
100 µl/$904
BHLHB2 / DEC1 Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
100 µl/$904
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa350-C-term) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$483
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
BHLHB2 / DEC1 Rabbit anti-Human Polyclonal (aa22-51) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
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