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Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
Gene Name: | basic helix-loop-helix family, member a15 |
Synonyms: | BHLHA15, BHLHB8, Class II bHLH protein MIST1, MIST-1, MIST1 |
Target Sequences: | NM_177455 NP_803238.1 Q7RTS1 |
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