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This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Gene Name: | transforming growth factor, beta receptor III |
Synonyms: | TGFBR3, Betaglycan, BGCAN, TGF-beta receptor type 3, TGF-beta receptor type III, TGFR-3, Betaglycan proteoglycan, Tgf-beta receptors type iii |
Target Sequences: | NM_003243 NP_003234.2 Q03167 |
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