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BDNF

brain-derived neurotrophic factor

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene Name: brain-derived neurotrophic factor
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: BDNF, ANON2, Abrineurin, BULN2, Neurotrophin
Target Sequences: NM_001709 NP_001700.2 P23560

Publications (8)

1
Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. PloS one. 2014 9:e95762. (Flo; Rat) [Full Text Article] [PubMed:24752645] [PMC:PMC3994132] Related Antibodies: LS-B3815.
2
Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor. Jiang H, Zhang X, Lu J, Meng H, Sun Y, Yang X, Zhao B, Bao T. Frontiers in psychiatry. 2018 March;9:102. (Human) [Full Text Article] [PubMed:29636708] [PMC:PMC5880910] Related Antibodies: LS-C343943.
3
TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma. Moriwaki K, Ayani Y, Kuwabara H, Terada T, Kawata R, Asahi M. Oncotarget. 2018 May;9:25225-25243. (Human) [Full Text Article] [PubMed:29861866] [PMC:PMC5982746]
4
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
5
Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice. Huijuan Shu , Zhongxin Guo , Xiangren Chen , Shuya Qi , Xinxin Xiong , Shuang Xia , Qingyun Huang , Ling Lan , Jiangu Gong , Shaoming Huang , Boning Yang , Guohe Tan. Aging and Disease. 2021 Apr;12:371-385. [Full Text Article] [PubMed:33815871] [PMC:PMC7990353] Related Antibodies: LS-C196746.
6
Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Kumarpillai Gopukumar, Shefali Thanawala, Venkateswarlu Somepalli, T S Sathyanaryana Rao, Vijaya Bhaskar Thamatam, Sanjaya Chauhan. Evidence-based complementary and alternative medicine : eCAM. 2021 December;2021:8254344. [Full Text Article] [PubMed:34858513] [PMC:PMC8632422]
7
Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy. Heba Bassiony Ghanem, Marwa Nagy Emam, Ali Dareen Abdelaziz Mohammed, Abd-Ellatif Rania Nagi. Reports of biochemistry & molecular biology. 2021 October;10:362-372. [Full Text Article] [PubMed:34981012] [PMC:PMC8718772]
8
BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer. Kazumasa Moriwaki , Masaki Wada , Hiroko Kuwabara, Yusuke Ayani, Tetsuya Terada, Masaaki Higashino, Ryo Kawata, Michio Asahi. Scientific reports. 2022 October;12:17553. [Full Text Article] [PubMed:36266462] [PMC:PMC9584965]
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BDNF ELISA Kit
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96-Well Microplate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$559
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96-Well Microplate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum
1 Plate/$559
BDNF ELISA Kit
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96-Well Microplate
Rat
12.29 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
BDNF ELISA Kit
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96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Biological Fluids, Plasma, Serum, Tissue Homogenates
1 Plate/$669
BDNF ELISA Kit
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96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$741
BDNF ELISA Kit
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Sandwich
96-Well Microplate
Human
0.3125 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$675
BDNF ELISA Kit
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96-Well Strip Plate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
BDNF ELISA Kit
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Sandwich
96-Well Microplate
Human
0.066 - 16 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
BDNF ELISA Kit
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96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$622
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$582
BDNF ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
47 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
BDNF ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BDNF ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$987; 1000 Wells/$1,422
BDNF ELISA Kit
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Sandwich
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Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$748
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Sandwich
96-Well Strip Plate
Guinea pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$817
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$779
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$783
BDNF ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$585
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).