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BDNF

brain-derived neurotrophic factor

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene Name: brain-derived neurotrophic factor
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: BDNF, ANON2, Abrineurin, BULN2, Neurotrophin
Target Sequences: NM_001709 NP_001700.2 P23560

Publications (8)

1
Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats. McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE. PloS one. 2014 9:e95762. (Flo; Rat) [Full Text Article] [PubMed:24752645] [PMC:PMC3994132] Related Antibodies: LS-B3815.
2
Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor. Jiang H, Zhang X, Lu J, Meng H, Sun Y, Yang X, Zhao B, Bao T. Frontiers in psychiatry. 2018 March;9:102. (Human) [Full Text Article] [PubMed:29636708] [PMC:PMC5880910] Related Antibodies: LS-C343943.
3
TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma. Moriwaki K, Ayani Y, Kuwabara H, Terada T, Kawata R, Asahi M. Oncotarget. 2018 May;9:25225-25243. (Human) [Full Text Article] [PubMed:29861866] [PMC:PMC5982746]
4
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
5
Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice. Huijuan Shu , Zhongxin Guo , Xiangren Chen , Shuya Qi , Xinxin Xiong , Shuang Xia , Qingyun Huang , Ling Lan , Jiangu Gong , Shaoming Huang , Boning Yang , Guohe Tan. Aging and Disease. 2021 Apr;12:371-385. [Full Text Article] [PubMed:33815871] [PMC:PMC7990353] Related Antibodies: LS-C196746.
6
Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Kumarpillai Gopukumar, Shefali Thanawala, Venkateswarlu Somepalli, T S Sathyanaryana Rao, Vijaya Bhaskar Thamatam, Sanjaya Chauhan. Evidence-based complementary and alternative medicine : eCAM. 2021 December;2021:8254344. [Full Text Article] [PubMed:34858513] [PMC:PMC8632422]
7
Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy. Heba Bassiony Ghanem, Marwa Nagy Emam, Ali Dareen Abdelaziz Mohammed, Abd-Ellatif Rania Nagi. Reports of biochemistry & molecular biology. 2021 October;10:362-372. [Full Text Article] [PubMed:34981012] [PMC:PMC8718772]
8
BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer. Kazumasa Moriwaki , Masaki Wada , Hiroko Kuwabara, Yusuke Ayani, Tetsuya Terada, Masaaki Higashino, Ryo Kawata, Michio Asahi. Scientific reports. 2022 October;12:17553. [Full Text Article] [PubMed:36266462] [PMC:PMC9584965]
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Antibodies (207)
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BDNF (207)
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BDNF Antibody - Anti-BDNF antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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Neuroscience
BDNF Goat anti-Human Polyclonal (aa183-194) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
BDNF Antibody - Mouse Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
BDNF Chicken anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$460
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BDNF Mouse anti-Human Monoclonal Antibody
Human
ELISA, Neut, WB
Unconjugated
100 µg/$860
BDNF Antibody - Anti-Human/Murine/Rat BDNF Western Blot Reduced
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
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BDNF Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$807
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BDNF Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$832
BDNF Antibody - Western blot of recombinant BDNF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BDNF Rabbit anti-Horse Polyclonal (aa128-247) Antibody
Horse
WB
Unconjugated
100 µl/$319; 200 µl/$366; 500 µl/$521; 1 ml/$599; 2 ml/$829; 5 ml/$1,359
BDNF Antibody - BDNF antibody IHC-paraffin: Rat Brain Tissue.
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BDNF Rabbit anti-Human Polyclonal (aa129-247) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
BDNF Antibody - Immunofluorescence of monoclonal antibody to BDNF on HeLa cell . [antibody concentration 10 ug/ml]
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BDNF Mouse anti-Human Monoclonal (1B10) Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$423
BDNF Antibody - Formalin-fixed and paraffin-embedded human brain reacted with BDNF Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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BDNF Rabbit anti-Human Polyclonal (aa206-236) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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BDNF Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
500 µg/$763; 1 mg/$957
BDNF Antibody - Immunofluorescence of HeLa cells using BDNF mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)
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BDNF Mouse anti-Human Monoclonal (aa19-248) (3D9C5) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$459
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BDNF Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$688
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$393
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BDNF Mouse anti-Human Monoclonal (aa19-247) (TS106) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µg/$896
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BDNF Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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BDNF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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BDNF Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
BDNF Antibody - Western blot of extracts of SH-SY5Y cell and PC-12 cell lines, using BDNF antibody.
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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BDNF Sheep anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
500 µg/$649
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BDNF Sheep anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$393
BDNF Antibody - Anti-BDNF Antibody. Lane A: K562 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 27 kDa. Observed band size: 27 kDa.
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BDNF Rabbit anti-Mouse Monoclonal (Preservative Free) (010) Antibody
Mouse
ELISA, WB
Unconjugated, Preservative Free
100 µl/$412
BDNF Antibody
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BDNF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$332
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BDNF Chicken anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
500 µg/$729
BDNF Antibody - Western Blot; Sample: Recombinant protein.
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BDNF Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$483; 1 ml/$551
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).