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BCL3 / BCL-3 is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.
Gene Name: | B-cell CLL/lymphoma 3 |
Family/Subfamily: | Cancer |
Synonyms: | BCL3, B-cell CLL/lymphoma 3, B-cell leukemia/lymphoma 3, B-cell lymphoma 3 protein, BCL-3, BCL4, D19S37, Proto-oncogene BCL3 |
Target Sequences: | NM_005178 NP_005169.2 P20749 |
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