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BCL2L2 / Bcl-w
BCL2-like 2
BCL2L2 / Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
| Gene Name: | BCL2-like 2 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | BCL2L2, BCLW, BCL2-L-2, KIAA0271, PPP1R51, Apoptosis regulator Bcl-W, Bcl-2-like protein 2, BCL-W, BCL2-like 2 |
| Target Sequences: | NM_004050 NP_004041.1 Q92843 |
Publications (2)
1
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Ernesto Diaz-Flores, Evan Q Comeaux, Kailyn L Kim, Ella Melnik, Kyle Beckman, Kara L Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S Braun, Charles G Mullighan, Mignon L Loh. Cancer research. 2019 May;79:2339-2351. [Full Text Article]
[PubMed:30862722]
[PMC:PMC6497548]
Related Antibodies: LS-C382259.
2
CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation. Rubina Tuladhar, Yunku Yeu, John Tyler Piazza, Zhen Tan, Jean Rene Clemenceau, Xiaofeng Wu, Quinn Barrett, Jeremiah Herbert, David H Mathews, James Kim, Tae Hyun Hwang, Lawrence Lum. Nature communications. 2019 September;10:4056. [Full Text Article]
[PubMed:31492834]
[PMC:PMC6731291]
Related Antibodies: LS-C382259.
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BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (100-180 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Neuroscience
BCL2L2 / Bcl-w Rabbit anti-Mouse Polyclonal (aa122-171) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
50 µl/$460
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
BCL2L2 / Bcl-w Rat anti-Human Monoclonal Antibody
Mouse, Dog, Rat, Human, Monkey
IP, WB
Unconjugated
100 µg/$863
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa74-88) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
Neuroscience
BCL2L2 / Bcl-w Rat anti-Human Monoclonal Antibody
Mouse, Dog, Rat, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
BCL2L2 / Bcl-w Mouse anti-Human Monoclonal (4G12E6) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
Neuroscience
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
BCL2L2 / Bcl-w Mouse anti-Human Monoclonal (4G12D11) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (Gly154) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa24-59) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa2-193) Antibody
Human
ELISA, IHC-P
Unconjugated
50 µg/$460
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal (aa131-180) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µl/$332
BCL2L2 / Bcl-w Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
BCL2L2 / Bcl-w Mouse anti-Human Monoclonal (2E4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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