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BCL2L12 encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.
Gene Name: | BCL2-like 12 (proline Rich) |
Family/Subfamily: | Apoptosis |
Synonyms: | BCL2L12, BPR, Bcl2-L-12, BCL2-like 12 (proline rich), Bcl-2-like protein 12 |
Target Sequences: | NM_138639 NP_619580.1 Q9HB09 |
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