Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles.Isoform Bcl-X(S) promotes apoptosis.
Gene Name: | BCL2-like 1 |
Family/Subfamily: | Apoptosis |
Synonyms: | BCL2L1, Apoptosis regulator Bcl-X, Bcl-xL, BCL-XL/S, BCLXS, Bcl-2-like protein 1, BCL2-like 1, BCL2L, Bcl-X, Bcl-xS, BCLXL, PPP1R52, Bcl2-L-1, BCLX |
Target Sequences: | NM_001191 NP_001182.1 Q07817 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.