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BCL2 / Bcl-2
B-cell CLL/lymphoma 2
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| Gene Name: | B-cell CLL/lymphoma 2 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50 |
| Target Sequences: | NM_000633 NP_000624.2 P10415 |
Publications (10)
1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP)
[PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65.
[PubMed:22065578]
[PMC:PMC3256916]
Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article]
[PubMed:27547187]
[PMC:PMC4974471]
☰ Filters
Products
Proteins
(17)
Type
Over-Expression Lysate
(5)
Recombinant
(12)
Target
BCL2 / Bcl-2
(17)
Publications
No
(17)
Tag
6His, C-terminus
(1)
6His, N-terminus
(2)
GST
(1)
GST, N-terminus
(1)
His
(3)
His, N-Terminal
(1)
His,C-terminus
(1)
His-GST
(1)
His-T7
(1)
Myc-DDK (Flag)
(5)
Species
Human
(12)
Mouse
(2)
Rat
(1)
Source
293T Cells
(2)
E. coli
(9)
HEK 293 Cells
(4)
Wheat Germ Extract
(2)
Purification
Purified
(3)
Low Endotoxin Level
Low endotoxin level
(2)
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
E. coli
His
26.8 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
E. coli
His-GST
27.2 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His, N-Terminal
27.4kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His-T7
27 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627
HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$1,107
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
26.1 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
22.2 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
22.2 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
26.1 kDa
100 µg/$494
E. coli
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.1 kDa
10 µg/$368; 50 µg/$479
Wheat Germ Extract
GST
52.7 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
6His, N-terminus
27 kDa
100 µg/$298
E. coli
6His, N-terminus
26.64 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
E. coli
His
24.7 kDa
100 µg/$721
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