BCL10 / BCL-10

B-cell CLL/lymphoma 10

Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-kB activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

BCL10 / BCL-10 (7)

Publications

No (7)

Tag

GST (1)

His (1)

His-SUMO (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human BCL10 / BCL-10 Protein (Recombinant His-SUMO) (Full Length) - LS-G20519

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

42.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human BCL10 / BCL-10 Protein (Recombinant His) - LS-G1677

Source:

E. coli

Tag:

His

Price:

10 µg/$361; 50 µg/$739; 20 µg/$486; 100 µg/$1,177; 250 µg/$1,788; 500 µg/$3,043

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Human BCL10 / BCL-10 Protein (Recombinant GST) (Full Length) - LS-G31402

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.7 kDa

Price:

2 µg/$439

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Human BCL10 / BCL-10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89218

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.1 kDa

Price:

20 µg/$150

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BCL10 / BCL-10 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117007

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.1 kDa

Price:

100 µg/$494

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Human BCL10 / BCL-10 Protein (Recombinant His-T7) (aa1-233) - LS-G24783

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.0 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse BCL10 / BCL-10 Protein (Recombinant His-T7) (aa1-233) - LS-G24784

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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