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BCHE / Cholinesterase

butyrylcholinesterase

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.

Gene Name: butyrylcholinesterase
Synonyms: BCHE, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, CHE1, Cholinesterase, Pseudocholinesterase, Butyrylcholinesterase, Cholinesterase 1
Target Sequences: NM_000055 NP_000046.1 P06276

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Products
Proteins (16)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (12)
BCHE / Cholinesterase (16)
No (16)
6His, C-terminus (2)
GST, N-terminus (1)
His (6)
His, N-Terminal (3)
His-T7 (1)
Myc-DDK (Flag) (3)
Dog (2)
Human (11)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (4)
Human Cells (3)
Mammalian Cells (1)
Wheat Germ Extract (1)
Yeast (2)
Purified (2)
Low endotoxin level (4)
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
66.7 kDa
50 µg/$710
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
66.12kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
BCHE / Cholinesterase Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
BCHE / Cholinesterase Protein - Purified recombinant protein BCHE was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
68.2 kDa
20 µg/$1,107
Select
E. coli
His
19.2 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
Yeast
His
17.1 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
BCHE / Cholinesterase Protein
Select
Yeast
His
67 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
BCHE / Cholinesterase Protein - Recombinant  Butyrylcholinesterase By SDS-PAGE
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E. coli
His-T7
30.2 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
BCHE / Cholinesterase Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
68.2 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
68.2 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
66.5 kDa
50 µg/$710
Select
HEK 293 Cells
His, N-Terminal
~65 kDa
200 µl/$283
Select
HEK 293 Cells
His, N-Terminal
~65 kDa
100 µg/$298
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
66.1 kDa
10 µg/$344; 50 µg/$584
Select
E. coli
His, N-Terminal
23.5kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
BCHE / Cholinesterase Protein - Recombinant Butyrylcholinesterase By SDS-PAGE
Select
E. coli
His
14.8 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).