BBC3 / PUMA

BCL2 binding component 3

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

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Products

Proteins (9)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (4)

Recombinant (4)

Target

BBC3 / PUMA (9)

Publications

No (9)

Tag

6His, N-terminus (1)

His, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Rat (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (5)

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Human BBC3 / PUMA Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ala2-Asn193) - LS-G26891

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

30-40 kDa

Price:

200 µl/$283

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Human BBC3 / PUMA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68292

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.4 kDa

Price:

20 µg/$1,107

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Human BBC3 / PUMA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68291

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.3 kDa

Price:

20 µg/$1,107

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Rat BBC3 / PUMA Protein (Recombinant His-T7) (aa76-170) - LS-G24547

Source:

E. coli

Tag:

His-T7

Molecular Weight:

14.5 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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BBC3 / PUMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101214

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.4 kDa

Price:

100 µg/$494

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Human BBC3 / PUMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81869

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.4 kDa

Price:

20 µg/$150

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Human BBC3 / PUMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81870

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.3 kDa

Price:

20 µg/$150

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Human BBC3 / PUMA Protein (Recombinant His, N-terminus) - LS-G146202

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

20.1kDa

Price:

20 µg/$270; 100 µg/$390

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BBC3 / PUMA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124586

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.3 kDa

Price:

100 µg/$494

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